杂志名称：AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

IF(2022-2024年）：24.7

发表时间：2019 Feb.

Abstract

The interaction between ventilation and lung perfusion is fundamental for effective gas exchange. Increasingly, clinicians are seeking to understand ventilation-perfusion matching at the bedside. Electrical impedance tomography (EIT) is emerging as the most promising bedside tool to define regional ventilation; being non-invasive, radiation-free and offering continuous monitoring across different clinical environments. The ability to determine lung perfusion at the bedside is limited, especially in infants. EIT can measure the heart-beat related impedance signal within the chest, and has been proposed as a method of also defining regional lung perfusion. Unlike the impedance signal during ventilation, the cardiac signal is of lower amplitude and occurs at a faster and more variable rate. This, and a lack of a true biological model, has limited validating EIT measures of lung perfusion.

Herein we report the case of a 13-day old infant born with an antenatal complete left pulmonary artery thrombosis and infarction of the left lung. This resulted in an almost complete absence of ventilation and perfusion in the left lung and a normal right lung. This provides a unique natural biological model in which to determine the role of perfusion and direct cardiac movement within the heart-beat related signal generated during EIT.

https://pubmed.ncbi.nlm.nih.gov/30365365/